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Significance in clinical medicine

The CO-rebreathing method to determine haemoglobin mass and the absolute volume of blood is world-wide used as the gold standard in sports medicine; i.e. for performance diagnostics, control of altitude training effects, talent diagnostics, and anti-doping purposes. In the recent 5 years, more than 90% of all scientific studies on haemoglobin mass and blood volume were performed using the “optimized CO-rebreathing method”.

Also in clinical medicine the exact knowledge of blood volume and haemoglobin mass is valuable in a variety of situations and is facing growing interest:

Blood transfusion
In case of occult blood loss as it frequently occurs in intensive care patients and during surgery it is difficult to determine the required transfusion volume. The exact knowledge of
the prevailing blood volume and haemoglobin mass helps to avoid over- or under- transfusion. Haemoglobin concentration in contrast is only a rough predictor for diagnosis.

Heart failure
Malfunction of the right or left ventricle can lead to congestion or edema with perilous consequences. The exact knowledge of the prevailing blood volume helps to adequately reduce the excessive volume.

Hematopoiesis disorder
To diagnose erythropoietic disorders and to evaluate its severity the knowledge of the exact amount of red cells and plasma volume is helpful. In case of the frequently occurring combined heart failure and chronic kidney disease data of haemoglobin mass allow an optimal adjustment of blood volume and an optimal dosage of erythropoietin.

Dialysis
The dilatation of the left ventricle due to an excessive blood volume is one of the most common causes of death in dialysis patients. Long term direct monitoring of blood volume prevents a volume overload and cardiac damage. During dialysis, blood volume monitoring avoids acute volume oscillations and the accompanying complications.

If your are interested in conducting studies in these areas we are pleased to collaborate